Enturia

What is ChloraPrep?

ChloraPrep — a proven system for patient preoperative skin preparation

ChloraPrep applicators help improve patient outcomes by reducing skin microorganisms that can cause bloodstream infections (BSIs) and surgical site infections (SSIs). The 2% CHG/70% IPA formulation and single-use applicators provide a proven system for infection control compliance across major and minor procedures.

Formulation

ChloraPrep is a combination of 2% chlorhexidine gluconate (CHG) and 70% isopropyl alcohol (IPA).

ChloraPrep provides two distinct mechanisms of action:

• IPA rapidly kills microorganisms by denaturing cell proteins
• CHG maintains persistent antimicrobial activity by disrupting the cell membrane and precipitating cell contents

Device

• ChloraPrep sterile, single-use applicators promote aseptic technique
  – Applicators eliminate direct hand-to-patient contact, helping prevent cross-contamination
• The sponge applicators’ gentle-friction scrub helps the solution to penetrate the first five cell layers of the epidermis where 80% of microorganisms reside¹ that can cause BSIs and SSIs
• Applicators ensure a smooth flow of solution

The ChloraPrep advantage versus traditional iodophors

ChloraPrep provides superior, rapid-acting, persistent, and broad-spectrum antisepsis compared to traditional iodophors.

• Rapid acting: The 70% isopropyl alcohol in ChloraPrep rapidly kills microorganisms versus free iodine, which requires two minutes to begin antimicrobial activity²
• Persistent: ChloraPrep maintains antimicrobial activity for at least 48 hours^3,4 compared to two hours for free iodine²
• Broad spectrum: ChloraPrep antimicrobial activity is effective against microorganisms including gram-positive and gram-negative bacteria, Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococci (VRE), Clostridium difficile, Acineobacter, and most viruses and fungi^2,4,5
• Active in protein-rich biomaterials: Remains active in the presence of blood, serum and other protein-rich biomaterials^5,6 unlike traditional iodophors, which are neutralized⁷
• Low irritation: CHG demonstrates low incidence of irritation⁵

Clinical evidence

When used with other CDC-recommended interventions, ChloraPrep reduced catheter-related BSIs by 89.3% in a Brookdale University Medical Center Clinical Study⁸. And, in a clinical study that compared two other surgical preparation solutions to ChloraPrep, the study determined that ChloraPrep was the most efficacious for eliminating bacteria from the hallux and toe sites (P<0.0001).⁹

The following studies demonstrate the superiority of ChloraPrep as a patient preoperative skin preparation:

• Evaluation of 2% CHG and 70% IPA formulation
  Evaluation of ChloraPrep for Patient Preoperative Skin Preparation

• ChloraPrep: Most effective solution compared to DuraPrep™ and Techni-Care®
  Efficacy of Surgical Preparation Solutions in Foot and Ankle Surgery

• ChloraPrep reduces blood culture contamination rates
  ChloraPrep vs Tincture of Iodine for Patient Preinjections Skin Preparation

Additional clinical studies supporting 2% CHG and CHG formulations
Review more than 30 clinical studies that support the efficacy of 2% chlorhexidine and chlorhexidine-based solutions as superior patient preoperative skin preparation antiseptics.

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DuraPrep is a trademark of 3M Health Care; Techni-Care is a registered trademark of Care-Tech Laboratories, Inc.