Enturia

Formulation

ChloraPrep: A preferred antimicrobial for reducing microorganisms

ChloraPrep, a combination of 2% chlorhexidine gluconate (CHG) and 70% isopropyl alcohol (IPA), helps improve clinical patient outcomes. ChloraPrep helps reduce the skin-dwelling microorganisms that can cause bloodstream infections (BSIs) and surgical site infections (SSIs). The efficacious formulation and single-use applicator system supports infection control guidelines to help reduce the incidence of BSIs and SSIs.

Active ingredients: 2% chlorhexidine gluconate w/v and 70% isopropyl alcohol v/v

• The Centers for Disease Control and Prevention (CDC) highly recommends using a 2% chlorhexidine solution as a skin antiseptic to help reduce catheter-related bloodstream infections (CRBSIs)
• The CDC recommends proper skin antisepsis to help reduce the incidence of surgical site infections

Indication: Patient preoperative skin preparation

• Skin antisepsis prior to intravenous or extended-dwell catheter placement, phlebotomy for blood culture or surgical procedures. For details on intended use, see product line page

Route of administration

• Topical application for intact skin

Pharmacological Class

• Topical antiseptic
• Chlorhexidine is a cationic bisbiguanide

The ChloraPrep combination of 2% CHG and 70% IPA provides two mechanisms of action

• IPA rapidly kills microorganisms by denaturing cell proteins
• CHG maintains persistent antimicrobial activity by disrupting the cell membrane and precipitating cell contents

Delivery device

ChloraPrep single-use applicators eliminate direct hand-to-patient contact

• Sterile, patented applicators reduce the risk of preparation-site contamination
• No hand-to-patient contact minimizes risk of cross-contamination
• Standardized protocol for use promotes aseptic technique
• One-step, ergonomic design ensures smooth flow of solution with one hand

ChloraPrep provides broad-spectrum action and remains active in blood

• Broad spectrum: ChloraPrep antimicrobial activity is effective against microorganisms including gram-positive and gram-negative bacteria, Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococci (VRE), Clostridium difficile, Acineobacter, and most viruses and fungi^2,3,4
• Active in protein-rich biomaterials: Remains active in the presence of blood, serum and other protein-rich biomaterials^3,5 unlike traditional iodophors, which are neutralized⁹

Clinical recommendations support efficacy of ChloraPrep formulation

• According to Prevention of Perioperative Infection, chlorhexidine gluconate is superior to povidone-iodine for preoperative skin antisepsis⁶
• Compared with DuraPrep™ and Techni-Care^®, ChloraPrep was shown to be the most effective solution for eliminating bacteria from the hallux and toe sites (P<0.0001) in a foot and ankle surgery study⁷
• According to Current Approaches for the Prevention of Surgical Site Infections, CHG agents are more effective than other antiseptics for reducing skin and wound microbial counts, thus decreasing SSIs⁸

Additional clinical studies for 2% CHG

Review more than 30 clinical studies that support the efficacy of a 2% chlorhexidine solution as a superior patient preoperative skin preparation.

DuraPrep is a trademark of 3M Health Care; Techni-Care is a registered trademark of Care-Tech Laboratories, Inc

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